Nucleobindin 1 Caps Human Islet Amyloid Polypeptide Protofibrils to Prevent Amyloid Fibril Formation

Binuclear ruthenium complexes inhibit the fibril formation of human islet amyloid polypeptide

The deposition of human islet amyloid polypeptide (hIAPP) is closely correlated with type II diabetesmellitus (T2DM). hIAPPmisfolding, as a significant causative factor of T2DM, can lead to the failure of islet transplant. Therefore, preventing the aggregation of hIAPP is one of the most vital factors to treat T2DM. Mononuclear Ru complexes have recently been proved to inhibit the aggregation o...

Genetic background determines the extent of islet amyloid formation in human islet amyloid polypeptide transgenic mice.

Genetic background is important in determining susceptibility to metabolic abnormalities such as insulin resistance and beta-cell dysfunction. Islet amyloid is associated with reduced beta-cell mass and function and develops in the majority of our C57BL/6J x DBA/2J (F(1)) male human islet amyloid polypeptide (hIAPP) transgenic mice after 1 yr of increased fat feeding. To determine the relative ...

Oophorectomy promotes islet amyloid formation in human islet amyloid polypeptide transgenic mice.

Micelle formation by a fragment of human islet amyloid polypeptide.

Human islet amyloid polypeptide (hIAPP) is the major component of amyloid plaques found in the pancreatic islets of persons with type 2 diabetes mellitus. HIAPP belongs to the group of amyloidogenic proteins, characterized by their aggregation and deposition as fibrillar amyloid in various body tissues. The aggregation of amyloidogenic proteins is thought to occur via a common pathway, but curr...

Extracellular vesicles from human pancreatic islets suppress human islet amyloid polypeptide amyloid formation.

Extracellular vesicles (EVs) are small vesicles released by cells to aid cell-cell communication and tissue homeostasis. Human islet amyloid polypeptide (IAPP) is the major component of amyloid deposits found in pancreatic islets of patients with type 2 diabetes (T2D). IAPP is secreted in conjunction with insulin from pancreatic β cells to regulate glucose metabolism. Here, using a combination ...